Accumulation stability of flavonoids as a species characteristic Lamiaceae family
https://doi.org/10.18619/2072-9146-2025-3-55-60
Abstract
The aim. The work evaluates 14 economically significant species from the Lamiaceae family. The aim of the work is a comparative assessment of the species from Lamiaceae family by the stability of the composition of raw materials depending on the year weather conditions, which will allow predicting the raw materials quality for its use and processing.
Methods. The focus of the work is on determining the yield and flavonoid content. The yield was determined in 4-fold repetition; the size of the plot was 0.66 m2 (1 linear meter with 60 cm row spacing). The sum of flavonoids was been determined by the spectrophotometric method («Shimadsu» spectrophotometer).
Results. The optimal harvesting period for the study-selected species is the beginning of mass flowering, which in the Moscow region falls on the last ten days of June – the first ten days of July. The maximum yield on average over 4 years was in Monarda fistulosa (350±42 g/m2), Nepeta grandiflora (363±40 g/m2) and Dracocephalum moldavica (440±76 g/m2). Based on the average four-year values, the maximum flavonoid content was noted in peppermint raw materials (3.52%), and in 2017 and 2018 it exceeded 4%. The flavonoid content was 1% and slightly more lower in Salvia officinalis (2.62%), Thymus serpyllum (2.44%), and Origanum vulgare (2.59%). The species 7 of the 14 studied had average values within 2-3%.
Conclusion. Flavonoid accumulation in plants of the Lamiaceae family is species-specific and varies greatly from year to year. Only Agastache foeniculum has a stable flavonoid content, as indicated by a variation coefficient below 10%. Dracocephalum moldavica, Monarda fistulosa, Thymus vulgaris, Thymus serpyllum, Origanum vulgare, and Satureja hortensis were been characterized by an average variation coefficient.
About the Authors
E. N. EremeevaRussian Federation
Elena N. Eremeeva – Cand. Sci. (Agriculture)
Researcher ID: 1186550
Timiryazevskaya Str., 49, Moscow, 127434
E. L. Malankina
Russian Federation
Elena L. Malankina – Dr. Sci. (Agriculture), Prof.
Timiryazevskaya Str., 49, Moscow, 127434
References
1. Hänsel R., Sticher O. Pharmakognosie. Phytopharmazie. 9. Auflage. Springer Medizin Verlag, Heidelberg. 2009:1098–1152. ISBN 978-3-642- 00962-4,
2. Burak M. & Imen Y. Flavonoids and their antioxidant properties. Тurkiye Klinikleri Journal of Medical Sciences. 1999;19:296–304.
3. Metodiewa D., Kochman A., Karolczak S. Evidence for antiradical and antioxidant properties of four biologically active N, N, diethylaminoethyl ethers of flavanone oximes: a comparison with natural polyphenolic flavonoid (rutin) action. Biochemistry and Molecular Biology International. 1997;41:1067–1075.
4. Walker E., Pacold M., Perisic O., et al. Structural determinations of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine. Molecular Cell. 2000;6:909–919.
5. Liu H., Ye F., Sun Q., Liang H., Li C., Li S., et al. Scutellaria baicalensis extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease in vitro. Journal of Enzyme Inhibition and Medicinal Chemistry. 2021;36:497–503. https://doi.org/10.1080/14756366.2021.1873977
6. Su H.X., Yao S., Zhao W.F., Li M.J., Liu J., Shang W.J., et al. AntiSARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients. Acta Pharmacologica Sinica. 2020;41:1167–1177. https://doi.org/10.1038/s41401-020-0483-6
7. Pei T., Yan M., Huang Y., Wei Y., Martin C. and Zhao Q. Specific Flavonoids and Their Biosynthetic Pathway in Scutellaria baicalensis. Frontiers in Plant Science. 2022;13:866282. https://doi.org/10.3389/fpls.2022.866282.
8. Martínez-Lüscher J., Torres N., Hilbert G., Richard T., Sánchez-Díaz M., Delrot S., et al. Ultraviolet B radiation modifies the quantitative and qualitative profile of flavonoids and amino acids in grape berries. Phytochemistry. 2014;102:106-114. https://doi.org/10.1016/j.phytochem.2014.03.014
9. Müller V., Albert A., Winkler J. B., Lankes C., Noga G., & Hunsche, M. Ecologically relevant UV-B dose combined with high PAR intensity distinctly affect plant growth and accumulation of secondary metabolites in leaves of Centella asiatica L. Journal of Photochemistry and Photobiology B: Biology. 2013;127:161-169. https://doi.org/10.1016/j.jphotobiol.2013.08.014
10. Idris A., Cuevas Linatoc A., Fadzelly M., Takai Z. I. and Audu Y. Effect of Light Quality and Quantity on the Accumulation of Flavonoid in Plant Species. Journal of Science and Technology. 2018;10(3):32-45. https://doi.org/10.30880/jst.2018.10.03.006
11. Del Valle J.C., Buide M.L., Casimiro-Soriguer I., Whittall J.B. and Narbona E. On flavonoid accumulation in different plant parts: variation patterns among individuals and populations in the shore campion (Silene littorea). Front. Plant Sci. 2015;6:939. https://doi.org/10.3389/fpls.2015.00939
12. Pei T., Yan M., Huang Y., Wei Y., Martin C. and Zhao Q. Specific Flavonoids and Their Biosynthetic Pathway in Scutellaria baicalensis. Frontiers in Plant Science. 2022;13:866282. https://doi.org/10.3389/fpls.2022.866282
13. Zhukova O.L., Àbramov A.A., Dargaeva T.D., Markarian A.A. Study on the phenol composition of the Camarum polustre soil covered organs. Moscow University Chemistry Bulletin. Chemistry. 2006;47(5):342-345.
14. Antonenko M.S., Zuikova E.Yu., Dul V.N., Malankina E.L. Accumulation of flavonoids in the Epilobium angustifolium L. raw material depending on the places of collection and part of the plant. Vegetable crops of Russia. 2023;(1):38-43. (In Russ.) https://doi.org/10.18619/2072-9146-2023-1-38-43. https://elibrary.ru/urkpvc
15. Sytar O., Zivcak M., Bruckova K., Brestic M., et al. Shift in Accumulation of Flavonoids and Phenolic Acids in Lettuce Attributable to Changes in Ultraviolet Radiation and Temperature. Scientia Horticulturae. 2018;239:193–204. https://doi.org/10.1016/j.scienta.2018.05.020
16. Mykhailenko O., Gudžinskas Z., Kovalyov V., Desenko V., Ivanauskas L., Bezruk I., et al. Effect of Ecological Factors on the Accumulation of Phenolic Compounds in Iris Species from Latvia, Lithuania and Ukraine. Phytochemical Analysis. 2020;31(5):545–563. https://doi.org/10.1002/pca.2918.
17. Leng P., Su, S., Wang, T., Jiang, X., & Wang, S. Effects of light intensity and light quality on photosynthesis, flavonol glycoside and terpene lactone contents of Ginkgo biloba L. seedlings. Journal of Plant Resources and Environment. 2002;(11):1-4.
18. Su,W., Zhang G., Li X., Gu F., Shi B. Effect of light intensity and light quality on growth and total flavonoid accumulation of Erigeron breviscapus. Chinese Traditional and Herbal Drugs. 2006;37:1244.
19. Hectors K., van Oevelen S., Guisez Y., Prinsen E., Jansen M.A. The phytohormone auxin is a component of the regulatory system that controls UV-mediated accumulation of flavonoids and UV-induced morphogenesis. Physiologia plantarum. 2012;145:594-603. https://doi.org/10.1111/j.1399-3054.2012.01590.x
20. Isah T. Stress and defense responses in plant secondary metabolites production. Biological Research. 2019;52(1):39. https://doi.org/10.1186/s40659-019-0246-3
21. Malankina E.L., Tkacheva E.N., Kozlovskaya L.N. Medicinal plants of the Lamiaceae family as sources of flavonoids. Bulletin of biological, medical and pharmaceutical chemistry. 2018;21(1):30-35. (In Russ.) https://doi.org/10.29296/25877313-2018-01-06.
22. Popov I.V., Chumakova V.V., Popova O.I., Chumakov V.F. Biologically active substances exhibiting antioxidant activity of some representatives of the Lamiaceae family cultivated in the Stavropol Territory. Khimija rastitel'nogo syr'ja. 2019;4:163–172. (In Russ.) https://doi.org/10.14258/jcprm.2019045200 https://elibrary.ru/ulywbc
23. Grebennikova O.A., Paliy A.Ye., Logvinenko L.A. Biologically active substances of Scutellaria вaicalensis Georgi of Nikita Botanical Gardens collection. Bulletin of the state Nikita botanical gardens. 2015;117: 60-66
24. Tutelyan V.A., Eller K.I. Methods of analysis of minor biologically active substances of food. М., 2010. 180 p. (In Russ.)
25. Voronina E.P., Gorbunov Yu. N., Gorbunova E.O. New aromatic plants for the Non-Black Earth Region.М.: Science, 2001. 172 р. (In Russ.)
26. Malankina E.L. Agrobiological substantiation of increasing the productivity of essential oil plants from the Lamiaceae L. family in the NonChernozem zone of Russia. Moscow, 2007. 343 р. (In Russ.) EDN QDXVEH.
27. Tkacheva E.N. Features of accumulation of biologically active substances with antioxidant activity by representatives of the Lamiaceae family. 170 с. (In Russ.) EDN KGEXXY.
28. Peshkova V. A. and Mirovich V. M. Flavonoids of Origanum vulgare. Chemistry of Natural Compounds. 1984;4:552. https://doi.org/10.1007/BF00574347
29. Kharazian N. Identification of flavonoids in leaves of seven wild growing Salvia L. (Lamiaceae) species from Iran. Progress in Biological Sciences. 2013;3(2):81-93.
Review
For citations:
Eremeeva E.N., Malankina E.L. Accumulation stability of flavonoids as a species characteristic Lamiaceae family. Vegetable crops of Russia. 2025;(3):55-60. (In Russ.) https://doi.org/10.18619/2072-9146-2025-3-55-60