Aqueous extract of Astilbe chinensis leaves as a potential medicine to slow activity of digestive enzymes
https://doi.org/10.18619/2072-9146-2025-1-88-91
Abstract
Relevance. Astilbe chinensis has clinical efficacy against many diseases, making this plant a potential natural source for treating diabetes and obesity with a mild, non-aggressive effect. Overall, the study of the biological properties of A. chinensis leaves is currently in its infancy.
Aim. In this study, the anti-amylase and anti-lipase potential of aqueous extract of Astilbe chinensis leaves was investigated as an important source of natural complex substances with therapeutic potential.
Methods. The total content of phenolic compounds was determined by the Folin-Ciocalteu method and flavonoids by the colorimetric method according to the complexation reaction with aluminum chloride. The effects of aqueous/tea extracts of A. chinensis leaves on pancreatic amylase and lipase were studied via in vitro models in comparison with acarbose and orlistat, respectively. For these tests, the artificial substrates 1,2-O-dilauryl-rac-glycero-3-glutaric acid ester (6-methylresorufin) and 2-chloro-4-nitrophenol oligosaccharide were used.
Results. The study of the effect of aqueous extract of A. chinensis leaves on pancreatic amylase and lipase showed a comparable inhibitory effect of 18% on both enzymes.
Supporting agencies: The work was carried out in accordance with the State Assignment on the topic FGUU 2022–0013.
About the Authors
E. V. Sokolova
All-Russian scientific research Institute of medicinal and aromatic plants
Russian Federation
Russian Federation
Ekaterina V. Sokolova – Cand. Sci. (Biology), Leading Researcher
7, Grin street, Moscow, 117216
T. N. Krol
All-Russian scientific research Institute of medicinal and aromatic plants
Russian Federation
Russian Federation
Tatiana A. Krol – Cand. Sci. (Agriculture), Leading Researcher
7, Grin street, Moscow, 117216
D. N. Baleev
All-Russian scientific research Institute of medicinal and aromatic plants
Russian Federation
Russian Federation
Dmitry N. Baleev – Cand. Sci. (Agriculture)
7, Grin street, Moscow, 117216
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Review
For citations:
Sokolova E.V., Krol T.N., Baleev D.N. Aqueous extract of Astilbe chinensis leaves as a potential medicine to slow activity of digestive enzymes. Vegetable crops of Russia. 2025;(1):88-91. (In Russ.) https://doi.org/10.18619/2072-9146-2025-1-88-91
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